Neuropathic pain is characterized by diabetic neuropathic peripheral pain (5) (24) and attack of herpes zoster following neuralgia (28). Pregabalin is the first drug of its kind used to treat diabetic neuralgia and post-herpatic neuralgia conserning with neuropathic pain. Pregabalin is also used to treat neuropathic pain, Fibromyalgia and Generalized Anxiety Disorders (GAD), a disorder characterized by a chronic illness impacting a person’s well-being and mental functioning ability (5). Clinical trials have shown that pregabalin has efficacy similar to the benzodiazepines and venlafaxine (4). Also it has been shown activity as anxiolytic, and sleep-modulating activities. Irritable bowel syndrome (IBS) is visceral hypersensitivity complex disorder that is having multiple characteristics and identified by abdominal pain and altered bowel habit, and often and mainly associated with other gastrointestinal symptoms, these symptoms include feelings of incomplete bowel movement and abdominal bloating, and extra-intestinal symptoms such as headache, dyspareunia, heartburn, muscle pain, and back pain(3). Pregabalin has anti-hyperalgesia properties similar to gabapentin since it is structurally similar to it. It is successfully used for peripheral neuropathic pain and for partial seizures. Gabapentin is used to treat chronic pain states and behavioral disorders and pregabalin was developed to alter and increase the pharmacological activity of gabapentin (17). This review article has been put on to focus the pharmacological activity of pregabalin and how this anti-epileptic drug is having multi-modal and quick onset of the pharmacological action with delayed potential in all of the disorder for which it is recommended.
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